However, although loss of endothelial MEF2C had no detected effects in physiological conditions, Xu et al. (2012) reported a significant increase in vascular recovery and a cognate decrease in pathological neovascularization in the Mef2C-null retinal vasculature after oxygen-induced retinopathy, indicating that loss of MEF2C results in increased sprouting after injury. The gene discussed is MEF2C; the disease is retinal disorder.