CRP and schizophrenia: In addition, maternal immune activation (MIA) also may contribute significantly to the increased risk of developing schizophrenia in the offspring,81 and it is proposed that once the acute inflammation subsides an abnormal ‘immune memory' may continue to be active in the offspring that then interferes with brain development into adulthood.82 The abnormal cytokine and CRP levels and the immune/inflammation co-expression module in the CP of people with schizophrenia may all be signatures of this abnormal ‘immune memory'.