CISH and schizophrenia: The majority of differentially expressed genes were upregulated in schizophrenia in both collections and many of the genes are involved in immune function and inflammation including the three genes common to both collections, SERPINA3, CISH and ADAMTS17. SERPINA3 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3) also known as alpha-1-antichymotrypsin, is a serine protease inhibitor and an acute phase protein that is induced during inflammation.