SEPTIN5 and bipolar disorder: Septins have roles in dendritic spine morphology,54 myelination,55 synaptic vescicle fusion,56 membrane curvature57 and cytoskeletal dynamics, which has been implicated in schizophrenia.58 Septin 5, 6 and 11 specifically have been implicated in schizophrenia and bipolar disorder previously in keeping with the proposed synaptic–dendritic basis to the disorders.59