In this study, we comprehensively evaluated the prognostic significance of 17 tagged single nucleotide polymorphisms (SNPs) in three key genes related to the Wnt pathway, WNT1, APC and CTNNB1, with regards to disease progression and all-cause mortality (ACM) in a cohort of prostate cancer patients treated with ADT. The gene discussed is APC; the disease is prostate carcinoma.