Shibata and colleagues evaluated Ig titers in patients with IS, noting that stroke was associated with a quick decrease in the titer of anti-tetanus toxoid IgG antibodies; that patients with white matter disease showed higher IgG antibodies titers to MBP and proteolipid protein; and finally confirmed the above-mentioned findings by Becker and co-workers [121], showing worse long-term outcome in association with high antibody titers to MBP. This evidence concerns the gene MBP and stroke disorder.