In Abcd1-deficient mice (Abcd1−; an X-ALD mouse model), astrocytosis and microgliosis, identified with glial fibrillary acidic protein (GFAP) and lectin staining, have been reported mainly in the pyramidal tracts and dorsal fascicles [12,13,14]. The gene discussed is GFAP; the disease is X-linked adrenoleukodystrophy.