To support this notion, sn‐1,2 DAG stereoisomers (in comparison to sn‐1,3 isomers) have been reported to be more potent at activating signalling pathways linked to insulin resistance, including the activation of PKC.56 Together, these studies provide emerging evidence that certain DAG molecules/isomers may play a more prominent role in the development of muscle atrophy, for example by promoting insulin resistance and/or increasing pro‐inflammatory drive. This evidence concerns the gene PRRT2 and Insulin resistance.