Thus, regulation of osteoporosis as well as inflammatory cytokines in the brain are important in the treatment of ischemic stroke, but previously reported peptides, such as thymosin β4 (Tβ4)22, synthetic fibronectin peptides23, 24, death-associated protein kinase 125 or laminin peptides26, did not affect the M/M or osteoclast differentiation. Here, FN1 is linked to osteoporosis.