In addition, Tohda et al. in 201246 have presented a docking simulation between ERp57/1,25D3-MARRS and diosgenin which is very similar in structure to calcitriol; in particular in this study they found that the exogenous stimulator diosgenin activates the 1,25D3-MARRS pathway, which may be a very critical signalling target for anti-AD (Alzheimer’s disease) therapy. The gene discussed is PDIA3; the disease is early-onset autosomal dominant Alzheimer disease.