We now showed that this feedback responses referring to induction of EGFR, and HER-2, was also elicited upon the pathway (AKT inhibitors) or oncogene (siRNA) blockade in both EGFR T790M mutant and EGFR wild type NSCLC cell lines (Figs 1 and 6). Here, ERBB2 is linked to non-small cell lung carcinoma.