EGFR and non-small cell lung carcinoma: For example, the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (e.g., gefitinib, erlotinib, and afatinib) have been successfully utilized and serve as the first-line therapy for late-stage NSCLC patients harboring EGFR-positive mutation8, 9, 10.