Of relevance to atopic dermatitis, the synthetic molecule 5,6-dihydroergosteol-glucoside (DHE-Glc) has also been shown to suppress TNF-α/IFN-γ-induced expression of CCL17 and CCL22 in the human keratinocyte cell line HaCaT, and attenuate levels of CCL22, CCL17 and IgE in a mouse model of atopic dermatitis as well as improve skin inflammatory symptoms59. The gene discussed is IGHE; the disease is atopic eczema.