Consistently, real-time PCR results showed that compared with normal dermis, the expression levels of collagen type I alpha1 (COL1A1), collagen type III alpha1 (COL3A1) and fibronectin 1 (FN1) were elevated by approximately 65-fold, 53-fold and 78-fold in keloid dermis, respectively (Fig. 1b). Here, COL3A1 is linked to keloid.