The top significant network consisted of 25 upregulated genes, which associate with protein synthesis, gene expression, and cancer (RPL13A, RPL41, RPL27A, RPLP0, RPL5, RPL11, RPL30, 60S ribosomal subunit, HSP90AA1, HSP, HSP90AB1, HSPA9, ENO1, 14-3-3, YWHAZ, RPS3, Tubulin, SAT1, GNB2L1, EIF4A, EIF4A1, TUBB, YWHAE, NOP56, PAPOLA) (Fig. 7b). The gene discussed is ENO1; the disease is cancer.