Microarray analysis also revealed that rhTFAM efficiently recovers the expression of 13 genes (MAP1B, GDI1, DCX, UCHL1, STMN1, ATXN10, CLASP2, PAK3, PFN2, MAP2, FNBP1L, RTN4, CCDC88A) among the 16 neuritogenesis-related genes downregulated in the PS1P117L AD neurons (Supplementary Fig. S9). The gene discussed is PFN2; the disease is Alzheimer disease.