PSIP1 and cancer: In our experience, cancer cell lines such as Jurkat, PC3, DU145, HeLa (including its derivative HEp-2), HCT116, and U2OS express elevated levels of DFS70/LEDGFp75, compared to non-cancer or non-transformed cell lines, thus providing excellent sources of this antigen for recognition by high titer anti-DFS antibodies [19, 20].