GLP1R and Hyperglycemia: In another study of healthy volunteers, treatment with the biguanide metformin was shown to have minimal effects on hyperglycemia associated with pasireotide SC exposure after an oral-glucose-tolerance test, whereas the dipeptidyl peptidase-4 inhibitor vildagliptin and the glucagon-like peptide-1 receptor agonist liraglutide were the most effective at restoring glucose to normal levels [30].