In a large, randomized, 12-month, Phase 3 trial (C2305 study) in medically naive patients with acromegaly, pasireotide LAR demonstrated superior biochemical control (composite end point of age-normalized IGF-1 and GH <2.5 ng/mL) in comparison with octreotide LAR (31.3 vs. 19.2 %; P = 0.007) [20]. Here, GH1 is linked to acromegaly.