Some reports indicate that CNVs heterozygous mutations in PARK2 associate with increased PD risk (Pankratz et al. 2011; Pankratz et al. 2009; Huttenlocher et al. 2015), while others found no differences for association (Wang et al. 2013; Kay et al. 2010). This evidence concerns the gene PRKN and Parkinson disease.