In view of our knowledge that a large number of genes are involved with HL, and that mutations in each gene would account for a small proportion of all HL, the discovery that mutations in a single gene GJB2 (DFNB1 locus), encoding connexin 26 (Cx26), accounted for a large proportion of recessive NSHL, came as an unexpected surprise (Kelsell et al. The gene discussed is GJB2; the disease is nodular sclerosis classical Hodgkin lymphoma.