Indeed, despite the hypothesis that the expression of PD-L1 on immune and tumor cells is correlated with efficacy, different companies have chosen different approaches to define target population and support their product effectiveness for the same indication (e.g., non-small cell lung cancer): nivolumab was tested and approved in overall patient population irrespective of PD-1 status and pembrolizumab in PD-1 positive patients (50% cutoff) only. Here, CD274 is linked to neoplasm.