It has been reported, indeed, that macrophages do express nicotinic receptors whose stimulation suppress cytokine synthesis by inhibiting the translocation of NF-κB from the cytoplasm to the nucleus (36) and Liu et al recently (37) showed that in a model of sepsis-induced lung damage in the rat, the antinflammatory effect of dexmedetomidine is attenuated by the nicotinic antagonist α-bungarotoxin. This evidence concerns the gene NFKB1 and Sepsis.