Orally administered EGCG activated PKCδ and aSMase in a murine MM xenograft model [47].In MM cells, phosphodiesterase 5 (PDE5), a major negative regulator of cGMP, is overexpressed and is able to reduce 67LR-mediated apoptosis induced by EGCG. The gene discussed is SMPD1; the disease is Miyoshi myopathy.