Silencing of 67LR resulted in abrogation of EGCG-induced apoptosis, confirming the role of 67LR in EGCG-mediated growth inhibition in MM cells [45].EGCG induced apoptosis through 67LR be determining phosphorylation of PKCδ and activation of acid sphingomyelinase (aSMase). The gene discussed is PRKCD; the disease is Miyoshi myopathy.