NOS2 and infection: In other pathogens such as P. brasiliensis and C. immitis, NO suppression has also been postulated to occur during infection, with an upregulation of IL-10 that reduces the expression of iNOS and the production of NO, and induction of the host enzyme arginase, which reduces the availability of arginine for iNOS, subsequently reducing the ability of the host to produce nitric oxide, respectively (Hung et al., 2007; Moreira et al., 2010).