Microphthalmia-associated transcription factor is a member of the MiT family of transcription factors, which include transcription factor EB (TFEB), the master regulator of lysosome biogenesis and autophagosomes formation, through the regulation of the expression of genes belonging to the coordinated lysosomal expression and regulation (CLEAR) network (161) in an mTOR-dependent manner (162). Here, TFEB is linked to microphthalmia.