BNIP3 and melanoma: Interestingly, the expression of the HIF1-responsive gene BCL-2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), an atypical BH3-only protein contextually implicated in the regulation of both cell death and autophagy (140), is constitutively higher in melanoma cells as compared to normal melanocytes (141).