However, a recent study also reported that decreased/loss of MITF expression in conjunction with an increased expression/activation of receptor tyrosine kinases (RTKs), like AXL and EGFR in melanoma cells correlated with increased cross-resistance toward MAPK pathway inhibitors and the induction of an invasive melanoma phenotype, suggesting that the oncogenic role of MITF is modulated by its cross talk with RTK pathways (159). This evidence concerns the gene EGFR and melanoma.