Multiple SNPs (rs7590268, rs6732426, rs13429458, rs17030845, rs12478601, rs7578597 and rs10495903) in the THADA gene have been reported to be associated with various complex traits or diseases: cleft palate (Ludwig et al., 2012, Mangold et al., 2010), hair morphology (Medland et al., 2009), polycystic ovary syndrome (Chen et al., 2011, Shi et al., 2012), platelet counts (Gieger et al., 2011), type 2 diabetes (Zeggini et al., 2008), IBD and Crohn's disease (Franke et al., 2010, Jostins et al., 2012). This evidence concerns the gene THADA and irritable bowel syndrome.