Two of the other three significant loci reported by Jostins et al. (rs7608910/rs13003464 and rs6088765/rs2425019) were also located or near SNPs under significant selection identified by our study, although not reported as IBD associated SNPs: rs13003464 was listed as a Celiac disease associated SNP and rs6088765 was near the UQCC/GDF5/CEP250 height associated region indexed by rs143384. This evidence concerns the gene GDF5 and irritable bowel syndrome.