Although the role of the GPBAR1 in LCA mediated signaling in healthy cells is currently under intense investigation (Tiwari & Maiti, 2009; Stepanov, Stankov & Mikov, 2013; Fiorucci & Distrutti, 2015; Li & Chiang, 2015; Perino & Schoonjans, 2015), nothing is known about its functions in prostate cancer cells. The gene discussed is GPBAR1; the disease is prostate carcinoma.