Del Villaer and Miller [177] demonstrated that differentially expressed in normal versus neoplastic (DENN)/MAPK activating death domain (MADD) protein, a TNFR1 binding protein, was down-regulated by Aβ in hippocampal neurons in AD patients and APP transgenic mice, allowing the TRADD-mediated TNFR1 apoptosis signaling. Here, TNFRSF1A is linked to Alzheimer disease.