TNFRSF1B and Alzheimer disease: Montgomery et al. [163] demonstrated that rAAV2 vector-mediated neuron-selective knockdown of TNFR2, but not TNFR1 or TNFR1 + 2, in 3xTg-AD mice led to a significantly dramatic enhancement of Aβ42 plaque deposition in a stage-dependent manner.