However, more importantly, we found a significantly lower expression of classical HLA class I in SCC paired metastatic tumor cells for HLA-A (P < 0.001, Wilcoxon Signed Rank test), HLA-B/C (P = 0.005, Wilcoxon Signed Rank test), and total classical HLA (P < 0.001, Wilcoxon Signed Rank test). The gene discussed is HLA-B; the disease is neoplasm.