For example, PD-1/PD-L1 receptors are differentially expressed in molecular subtypes of breast cancer (triple negative breast cancer (TNBC) vs. non-TNBC and colon cancer (CRC) (microsatellite-high (MSI-H) vs. microsatellite stable (MSS) cases). The gene discussed is PDCD1; the disease is colorectal carcinoma.