It has been previously shown that quantifying the densities of two lymphocyte populations—cytotoxic CD8+ T cells and memory T cells expressing CD45RO+ antigen, CD3+ and CD8+ T cells, or CD3+ and memory CD45RO+ T cells (CD3/CD45RO, CD3/CD8 or CD8/CD45RO)—both in the tumor core and in the invasive margin of tumors, termed “Immunoscore,” could predict survival of early-stage colorectal cancer patients [44, 45]. Here, CD8A is linked to neoplasm.