NKX2-1 and breast cancer: Widschwendter et al. investigated methylation of a few genes in a case–control study (n = 1083) and found that decreased DNA methylation in NUP155 (I), ZNF217 (II), PTGS2, TITF1, NEUROD1, and SFRP1 are associated with increased BC risk [14] (Fig. 3c).