NFKB1 and non-small cell lung carcinoma: Mechanistically, the Wnt5a activated Wnt5a/PKC signaling cascade and led to activation of endoplasmic reticulum (ER) release of Ca2+, PKC, and CaMKII, which in turn activated NFκB, subsequently promoted stemness, and inhibited apoptosis in NSCLC cells (Figure 9).