WNT5A and nasopharyngeal carcinoma: In addition, a recent high-throughput gene expression profiling further revealed that Wnt5a signaling was upregulated in highly metastatic nasopharyngeal carcinoma (NPC) cells and tissues, in which Wnt5a was able to activate PKC signaling and form a positive Wnt5a and phosphorylated PKC loop to promote the stemness characteristics of NPC cells, leading to an enhanced metastatic features and tumorigenicity in vitro and in vivo [21].