In order to access the potential impact of Wnt5a on metastatic properties of lung cancer cells, its effects on the proliferation, migration, and invasion in lung adenocarcinoma A549 cells and cisplatin-resistant A549/DDP cells were examined in terms of CCK assay for cell viability, scratch healing assay for cell migration, and transwell assay for cell invasion. The gene discussed is WNT5A; the disease is lung cancer.