Immunoblotting assay further identified that the Wnt5a-inhibited apoptosis and GF109203X-mediated increase of apoptosis were associated with a decreased and an increased expression of proapoptotic proteins of Bax, caspase 3, and apoptosis inducing factor (AIF) in lung cancer cells, respectively (Figure 8). The gene discussed is AIFM1; the disease is lung carcinoma.