In order to access the potential impact of Wnt5a on metastatic properties of lung cancer cells, its effects on the proliferation, migration, and invasion in lung adenocarcinoma A549 cells and cisplatin-resistant A549/DDP cells were examined in terms of CCK assay for cell viability, scratch healing assay for cell migration, and transwell assay for cell invasion. Here, WNT5A is linked to lung adenocarcinoma.