Above in vitro studies have clearly showed that the PKC inhibitor GF109203X could sufficiently inhibit the Wnt5a-induced cell migration, invasion, and clonogenicity in both A549 and A549/DDP lung cancer cells, implying that Wnt5a could promote lung cancer cell mobility by activation of Wnt/PKC noncanonical pathway. This evidence concerns the gene PRRT2 and lung cancer.