ROR2 and neoplasm: In addition to its oncogenic roles in cancers, Wnt5a also has been found to inhibit canonical Wnt/β-catenin signaling in a Ror2-dependent manner and has a tumor suppressor role in several cancer types, such as colorectal cancer (CRC) [55], thyroid cancer [56], and maybe breast cancers as well [34, 36, 57].