Based on the biology of the Fus1 protein (Uzhachenko et al., 2012, 2014, 2015; Yazlovitskaya et al., 2013, 2015) and on aging-associated pathways involved in cognitive decline, we included in the analysis the proteins representing pathways linked to (1) energy homeostasis (ACC1, ACC2, AMPK); (2) oxidative stress (PRDX1); (3) apoptosis and autophagy (Bcl-xL, LC3); (4) learning and memory (TrkB, NGFR, Calretinin, Rack1). This evidence concerns the gene BCL2L1 and Mental deterioration.