Considering the principal role of mitochondrial bioenergetics in neurodegenerative diseases including AD (Johri and Beal, 2012), here we demonstrate that loss/decrease of Fus1 may cause olfactory and spatial memory changes early in life, which are paralleled by molecular changes in the functionally relevant olfactory bulb and hippocampus. This evidence concerns the gene TUSC2 and Alzheimer disease.