In particular, we focused on the assessment of the value of our platform for the study of aSyn spreading, a central problem in PD and also in other neurodegenerative disorders such as Alzheimer's disease (AD), where Tau pathology has also been show to spread in the brains of animal models (de Calignon et al., 2012) and between co-cultured cells in vitro (Frost et al., 2009). Here, MAPT is linked to Alzheimer disease.