In addition, sphere formation ability and expression of the cancer stem-like cell proteins, Sox2, and Oct4 were upregulated by recombinant IL-4 and downregulated by anti-IL-4 antibody in A498 cells (Figure 3D), similar to the phenomena exhibited by MDA-MB-231 cells (Supplementary Figure S2A and 2B). The gene discussed is POU5F1; the disease is cancer.