IGF2 and neoplasm: Moreover, the tumor growth was also suppressed in the sh-HOTAIR group when compared to that in sh-Control group (Figure 6D), and sh-HOTAIR group had higher expression level of miR-663b in the tumor than that in sh-Control group (Figure 6E); also the mRNA and protein levels of IGF2 were down-regulated in sh-HOTAIR group (Figure 6F).