IGF2 and familial pancreatic carcinoma: QRT-PCR results showed that miR-663b expression was significantly lower in pancreatic cancer tissues than that in adjacent normal pancreatic tissues from patients with pancreatic cancer (Figure 4A); while the mRNA expression level of IGF2 was significantly increased in pancreatic cancer tissues when compared to adjacent normal pancreatic tissues from patients with pancreatic cancer (Figure 4B).