HOTAIR and familial pancreatic carcinoma: Moreover, HOTAIR disrupted the balance between H3K4me3 and H3K27me3 on the miR-663b promoter region, which may be associated with the hypermethylation status of miR-663b in the pancreatic cancer cells [29, 30]; thus HOTAIR suppressed the expression of miR-663b in pancreatic cancer cells.