Of the COX-2 inhibitors, parecoxib is one of the most well-known COX-2 selective inhibitors, which had been developed as a highly efficient postoperative analgesia drug with low adverse reaction, and parecoxib treatment was shown to exert a potent anticancer role in multiple human cancers, including colorectal cancer (Zagani et al., 2009; Xiong et al., 2015), esophageal adenocarcinoma (Santander et al., 2012). This evidence concerns the gene PTGS2 and esophageal adenocarcinoma.