In our study, 3D-cultured cancer cells preserved both MDM2 amplification and gene expression associated with liposarcoma pathogenesis and aggressiveness (Benassi et al., 2001; Gogou et al., 2012; Guo et al., 2008; Pazzaglia et al., 2004; Stratford et al., 2011; Somarelli et al., 2016), suggesting that this in vitro model could facilitate the identification of disease-specific biomarkers. The gene discussed is MDM2; the disease is cancer.