We also observed preneoplastic lesions and tumor tissue that were positive for GSTP1 (Fig. 8A; 5M N, 9M N, 12M T and 18M T in GSTP1), which simultaneously exhibited decreases in the expression of NOX4 (Fig. 8A; 5M N, 9M N, 12M T and 18M T in NOX4) of 38%, 27%, 52% and 59%, respectively (Fig. 8B) compared with that in UT liver tissue (Fig. 8A; UT in NOX4). The gene discussed is NOX4; the disease is neoplasm.