NOX4 and cancer: Overexpression of NOX4 has been demonstrated in various cancers (Kanda et al., 2015; Lee et al., 2007; Maranchie and Zhan, 2005; Yamaura et al., 2009) and in animal models, concomitant with the development of spontaneous fibrosis induced in genetically modified mouse models and with CCl4 (Sancho et al., 2012).