Some reports have shown that Casp3, some claudins and DUOX1 and DUOX2 are regulated by epigenetic mechanisms during maturation of the rat brain, as well as in ovarian cancer cells and lung cancer (Honda et al., 2007; Luxen et al., 2008; Yakovlev et al., 2010). The gene discussed is DUOX2; the disease is lung carcinoma.