EGFR and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), previous studies have reported mutations in β-catenin, overexpression of receptors (such as ErbB and MET), chromosomal gains in 1q, 6p, 8q, 17q and 20q and chromosomal losses in 1p, 4q, 8p, 13q and 17p (Farazi and DePinho, 2006; Forner et al., 2012).