Using a median cutpoint to distinguish between CD15high (n = 11, PA 3, 4, 8, 10, 11, 13, 16, 17, 19, 21, 22) and CD15low (n = 11, PA 1, 2, 5, 6, 7, 9, 12, 14, 15, 18, 20) adenomas, we investigated the expression of developmental genes Pax7 and Sox2, which we found to correlate with an increased rate of secondary sphere formation (Fig. 2d, e). This evidence concerns the gene SOX2 and adenoma.