With regard to our EDP method of rigorously selecting cohorts of N = 112 highly-sensitive (HS) light smokers with HNSCC and N = 99 highly resistant (HR) heavy smokers with no cancer, we conclude that the carefully chosen single-nucleotide variants located in and near four genes—AHR, CYP1A1, CYP1A2, CYP1B1, alone, or in combination—are not statistically significantly associated with risk of cigarette-smoking-induced HNSCC. This evidence concerns the gene CYP1A1 and head and neck squamous cell carcinoma.