Compared with malignancies in nonsmokers, smokers exhibit more tumors of the larynx, hypopharynx, and floor of the mouth; a much greater TP53 mutation rate; a substantially higher percent of loss of heterozygosity at Chr 3p, 4q, and 11q13; and a greater overall average number of chromosomal losses. This evidence concerns the gene TP53 and laryngeal neoplasm.