CYP2E1 and head and neck squamous cell carcinoma: (c) Another study, comparing 312 HNSCC cases and 300 noncancer controls, looked at the impact of 22 sequence variations in CYP1A1, CYP1B1, CYP2E1, GSTM1, and six other genes encoding either xenobiotic-metabolizing or DNA repair enzymes [13]; using logit regression and a Bayesian version of logit regression, authors found significant (P < 0.05) associations of CYP1B1 p.L432V and CYP2E1 −70G > T (O.R. 10.84; 95% CI, 1.64–71.53), as well as CYP1B1 p.L432V and GSTM1(0/0) null/null (OR 11.79; 95% CI, 2.18–63.77) with HNSCC risk.