For example, we found that ANRIL and HOTTIP expression levels were increased, while H19 and MEG3 expression levels were decreased, although these changes did not reach statistical significance in HCC tissues due to dramatically elevated expression of these two lncRNAs in some tumor tissues (Additional file 8: Figure S1 c, e), as also reported in other studies [44, 46]. This evidence concerns the gene HOTTIP and neoplasm.