To investigate if lncRNAs are differentially expressed in HCC of different viral etiology, we first employed the commercial Disease-Related Human LncRNA Profiler, which detects 83 lncRNAs implicated in a variety of human diseases, ranging from neurodegeneration to cancer, including 7 lncRNAs previously associated with HCC (ANRIL, H19, HOTAIR, HOTTIP, HULC, MALAT1 and MEG3). This evidence concerns the gene HOTAIR and hepatocellular carcinoma.