SPADH and cancer: Based on findings obtained by SEM (e.g., cellular protrusions formation) and phenotypic cancer assays (e.g., increased mobility, invasion, and anchorage independent growth), we first selected basigin (CD147) and CUB domain-containing protein (CDCP1) for cross-validation in connection with their previously established roles in cell motility, invasion, cellular protrusions formation, and metastasis in the context of the oncogenic KRas-driven transformation [50, 63].