TNF and Insulin resistance: The inflammation is explained by the presence of single nucleotides polymorphisms (SNPs) in specific genes, such as -174G/C promoter polymorphism of the IL-6 gene that correlates to insulin resistance [38, 39], polymorphism in IL-15 receptor alpha, in methylenetetrahydrofolate reductase (MTHFR) genes [40] and in G/A -308 Tumor Necrosis Factor-alpha (TNF-α).