As shown in this study, in the T47D breast cancer cell context, epigenetic effects due to increased inhibition of RARA transcriptional function result in the expansion of the pool of cells with high RA synthesis (ALDHhigh cells), including a subset of ALDHhigh/CD24low/CD44high cells, with increased stemness, pro-proliferative, and pro-invasive properties [45, 46]. The gene discussed is RARA; the disease is breast cancer.