ESR1 and cancer: We next analyzed the associations between SNPs in ACYP2 and patient clinicopathological features including age of menarche, tumor size (cm), duration of breast feeding (months), primiparous age, procreative times), clinical stage, lymph node (LN) metastasis, family history of cancer, incipient or recurrent tumor, estrogen receptor (ER) status, progesterone receptor (PR) status, tumor type, and fertility status.