PROM1 and cancer: For example, Tong et al. found that, enforced annexin A3 (ANXA3) enhanced cancer and stem cell-like properties in CD133+ liver CSCs by decreasing the activity of JNK [30]; Pan et al. reported that ANXA3 up-regulation in human Hepatocellular Carcinoma (HCC) may be a new prognostic biomarker, as ANXA3 promoted Hepatocellular Carcinoma cell proliferation, colony formation and migration [24].