ANXA3 and neoplasm: Furthermore, univariate analysis implied that overall survival was significantly correlated with ANXA3 expression (P < 0.001), depth of tumor infiltration(P = 0.027), TNM stage (P<0.001) and the local lymph node metastasis (N stage, P=0.012), Distant metastasis((P < 0.001), but not with sex, age, Tumor size (Table 2).