Analysis of clinicopathological parameters showed that high ANXA3 expression was striking related to Tumor size (P=0.006), depth of tumor infiltration (T stage, P<0.001), TNM stage (P<0.001), and the local lymph node metastasis (N stage, P=0.023), Distant metastasis(P=0.014) (Table 1). The gene discussed is ANXA3; the disease is neoplasm.