This clinical endpoint is also termed late AMD, which can appear as a wet form characterised by choroidal/sub-retinal neovascularisation (NV), or a dry form, known as geographic atrophy (GA) of the RPE.[2, 3] Therapeutic options for late AMD are limited: clinically effective treatments are currently restricted to anti-VEGF therapy for wet late AMD; the treatment is no cure, but rather slows down the progression of vision loss.[5–7]. The gene discussed is VEGFA; the disease is age-related macular degeneration.