IFNG and infection: In the case of the infection with the attenuated rabies virus CVS-F3 it has been shown that increased cerebellar blood-brain barrier permeability is accompanied by increased local synthesis of TNFα, interferon γ (IFNγ), and intercellular adhesion molecule-1 (ICAM-1) and occurs earlier in the cerebellum than in the cerebral cortex [37].