CADM1 and tropical spastic paraparesis: The frequency distribution of TCRVβ subunits in ACs and patients with HAM/TSP resembled that in healthy donors [44] (S1A and S2 Figs), with no significant difference in the OCI-flow of infected CADM1+CD3+ cells and the OCI-flow of predominantly uninfected CADM1−CD3+ cells (Fig 1B).