Treatment with SR (50 and 100 mg/kg) could significantly (p < 0.05–0.01) attenuate the expressions of the ICAM 1, MCP 1, IL 1β and IL 6 in the sera of T2D rats, while, VEGF and TNF α levels were significantly (p < 0.05) attenuated at the dose of 100 mg/kg of SR. Here, TNF is linked to type 2 diabetes mellitus.