SalB also reduces the expressions of inflammatory factors, such as interleukins (IL-1β, IL-6, and IL-8), alleviates apoptosis of vascular cells to improve heart function, reduces liver and renal fibrosis via down-regulating transforming growth factor β1 (TGF-β1) and depressing MMP-2 activity [30]. Here, TGFB1 is linked to renal fibrosis.