ALOX5 and atherosclerosis: Most attention has been focused on ALOX-5 and FLAP, where Dwyer et al. examined a tandem repeat polymorphism in the promoter region of ALOX-5 that was associated with higher intima-media thickness of the carotid arteries, a marker of atherosclerosis, when comparing carriers of the variant allele with homozygotes of the wild type allele [15].